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Physicochemical, Mechanical, and Biological Properties of Bone Cements Prepared with Functionalized Methacrylates

Grupo de Polímeros GPUSB, Dpto. Ciencia de los Materiales Laboratorio de Biotecnologíá, Dpto. de Biologíá Celular, Universidad Simon Bolivar, APTO 89000 Caracas 1080-A Venezuela

Diana Ajami

Grupo de Polímeros GPUSB, Dpto. Ciencia de los Materiales Laboratorio de Biotecnologíá, Dpto. de Biologíá Celular, Universidad Simon Bolivar, APTO 89000 Caracas 1080-A Venezuela

Vehid Salih

Division of Biomaterials and Tissue Engineering Eastman Dental Institute, University College London 256 Gray’s Inn Road, London, WC1X 8LD, UK

Showan N. Nazhat

Division of Biomaterials and Tissue Engineering Eastman Dental Institute, University College London 256 Gray’s Inn Road, London, WC1X 8LD, UK

Rossana Vargas-Coronado

Centro de Investigación Científica de Yucatán A.C. Calle 43 # 130, Col. Chuburná de Hidalgo, C.P. 97200, Mérida, Yucatán, México

Juan V. Cauich-Rodríguez

Centro de Investigación Científica de Yucatán A.C. Calle 43 # 130, Col. Chuburná de Hidalgo, C.P. 97200, Mérida, Yucatán, México, jvcr{at}cicy.mx

Ma Pau Ginebra

Department of Materials Science and Metallurgy Universidad Politécnica de Catalunya, Barcelona, Spain

Bone cements prepared with methyl methacrylate (MMA) as a base monomer and either methacrylic acid (MAA) or diethyl amino ethyl methacrylate (DEAEMA) as comonomers were characterized in terms of curing behavior, mechanical properties, and their in vitro biocompatibility.

The curing time and setting temperature were found to be composition dependent while the residual monomer was not greatly affected by the presence of either acidic or alkaline comonomers in the bone cements. For samples with MAA comonomer, a faster curing time and higher setting temperature were observed when compared to the cement with DEAEMA comonomer.

In terms of mechanical properties, the highest compressive strength was exhibited by formulations containing MAA, while the highest impact strength was shown by the formulations prepared with DEAEMA. There were no differences observed between the two formulations for tensile, shear, and bending strength values. Similarly, fatigue crack propagation studies did not reveal differences with the addition of either DEAEMA or MAA.

No differences were observed in the initial number of attached primary rat femur osteoblasts on the different bone cements and positive controls. However, after 48 h there was a reduced proliferation in the cells grown on bone cements containing MAA.

Key Words: bone cements • methacrylic acid • diethyl amino ethyl methacry-late • mechanical properties • biocompatibility • osteoblasts

Journal of Biomaterials Applications, Vol. 19, No. 2, 147-161 (2004)
DOI: 10.1177/0885328204045443


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