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Journal of Biomaterials Applications
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In vitro Biocompatibility of PTMO-based Polyurethanes and those Containing PDMS Blocks

Shan-Hui Hsu

Department of Chemical Engineering, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung, Taiwan 402, ROC, shhsu{at}nchu.edu.tw

Hsiang-Jung Tseng

Department of Chemical Engineering, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung, Taiwan 402, ROC

In this work, a series of different polyurethanes based on poly(tetramethylene oxide) (PTMO, MW 2000) and chain extended with butenediol were synthesized by a two-step solution polymerization. Three of them contained silanol terminated polydimethylsiloxane (PDMS, MW 2000) blocks. It was shown that these polymers exhibited various degrees of micro-phase separation that further influenced their biological performances in vitro. The formulation with diphenylmethane diisocyanate/PTMO/PDMS/2-butene-1,4-diol at a molar ratio of 2: 0.75: 0.5: 1 in synthesis was favorable due to a combination of enhanced mechanical properties, biostability, cellular affinity as well as platelet nonadherence.

Key Words: biocompatibility • biostability • microphase separation • polyurethane • polydimethylsiloxane

Journal of Biomaterials Applications, Vol. 19, No. 2, 135-146 (2004)
DOI: 10.1177/0885328204044160
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