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Journal of Biomaterials Applications
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Biomaterials in Periodontal Regenerative Surgery: Effects of Cryopreserved Bone, Commercially Available Coral, Demineralized Freeze-dried Dentin, and Cementum on Periodontal Ligament Fibroblasts and Osteoblasts

Didem Devecioglu

Faculty of Dentistry, Department of Periodontology, Hacettepe University, Ankara, TR-06100 Turkey

Tolga F. Tözüm

Faculty of Dentistry, Department of Periodontology, Hacettepe University, Ankara, TR-06100 Turkey, ttozum{at}hacettepe.edu.tr

Diilek Sengün

Faculty of Dentistry, Department of Periodontology, Hacettepe University, Ankara, TR-06100 Turkey

Rahime M. Nohutcu

Faculty of Dentistry, Department of Periodontology, Hacettepe University, Ankara, TR-06100 Turkey

The ultimate goal of periodontal therapy is to achieve successful periodontal regeneration. The effects of different biomaterials, allogenic and alloplastic, used in periodontal surgeries to achieve regeneration have been studied in vitro on periodontal ligament (PDL) cells and MC3T3-E1 cells. The materials tested included cryopreserved bone allograft (CBA), coralline hydroxyapatite (CH), demineralized freeze-dried dentin (DFDD), and cementum. CBA and CH revealed an increase in initial PDL cell attachment, whereas CH resulted in an increase in long-term PDL cell attachment. Mineral-like nodule formation was observed significantly higher in DFDD compared to other materials tested for osteoblasts. Based on the results of this in vitro study, we conclude that the materials used are all biocompatible with human PDL cells and osteoblasts, which have pivotal importance in periodontal regeneration.

Key Words: bone substitute • cell culture • biocompatibility • periodontal ligament • fibroblast • osteoblast

Journal of Biomaterials Applications, Vol. 19, No. 2, 107-120 (2004)
DOI: 10.1177/0885328204043818
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