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Journal of Biomaterials Applications
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Norfloxacin-loaded Chitosan Sponges as Wound Dressing Material

Em&unknown;r B. Denkbas

Chemistry Department, Biochemistry Division Hacettepe University, Ankara, Turkey

Eylem Öztürk

Chemistry Department, Biochemistry Division Hacettepe University, Ankara, Turkey

Nalan Özdem&unknown;r

Chemistry Department, Biochemistry Division Hacettepe University, Ankara, Turkey

Kaan Keçec&unknown;

Chemistry Department, Biochemistry Division Hacettepe University, Ankara, Turkey

Canan Agalar

Infection Diseases Division, SSK Diskapi Hospital, Ankara, Turkey

The aim of this study was the preparation and characterization of chitosan sponges including a model antibiotic (i.e., norfloxacin). The chitosan sponges were prepared by a solvent evaporation method. The matrix was also cross-linked during the preparation. The results indicated that the chitosan sponges were in the fibrillar structure. The swelling behavior, norfloxacin loading, in vitro release characteristics, and antibacterial activity were determined. The effects of cross-linker concentration, norfloxacin/chitosan ratio, chitosan molecular weight, and base concentration were investigated. The most effective parameter was found to be the degree of neutralization. It was also observed that the equilibrium swelling ratio decreased with increasing crosslinking density. The norfloxacin release was found to be swelling controlled initially and diffusion controlled at the extended release periods. It was also found that the antibacterial activity was directly proportional to the release rate.

Key Words: norfloxacin • chitosan sponge • wound dressing • drug release • antibacterial activity

Journal of Biomaterials Applications, Vol. 18, No. 4, 291-303 (2004)
DOI: 10.1177/0885328204041510
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Home page
 Journal of Bioactive and Compatible PolymersHome page
E. B. Denkbas and R. M. Ottenbrite
Perspectives on: Chitosan Drug Delivery Systems Based on their Geometries
Journal of Bioactive and Compatible Polymers, July 1, 2006; 21(4): 351 - 368.
[Abstract] [PDF]