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Journal of Biomaterials Applications
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Spinal Fixation Device: A 6-Year Postimplantation Study

Mira Mohanty

Division of Implant Biology Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology Thiruvananthapuram, Kerala - 695 012, India, mira{at}sctimst.ker.nic.in

Sulekha Baby

Division of Implant Biology Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology Thiruvananthapuram, Kerala - 695 012, India

K. V. Menon

Department of Orthopedics Amritha Institute of Medical Sciences and Research Centre Kochi, Kerala, India

Long-term tissue response to a metal device is described here. The components of a spinal fixation device were removed 6 years after implantation, following the need for revision surgery after a fall. Scanning electron microscopy (SEM) revealed changes in surface topography of the metal. Examination of the adjacent tissue showed a chronic inflammatory response with occasional metal debris. Immunohistochemistry identified the predominant macrophages and abundant neovascularization. The presence of macrophages in tissues adjacent to the implants, in an otherwise asymptomatic person, is noteworthy.

Key Words: spinal fixation device • metal • macrophages

Journal of Biomaterials Applications, Vol. 18, No. 2, 109-121 (2003)
DOI: 10.1177/088532803034746
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