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Journal of Biomaterials Applications
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Immunological Study of a Chitosan Prosthesis in the Sciatic Nerve Regeneration of the Axotomized Dog

M. Rosales-Cortés

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

J. Peregrina-Sandoval

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

J. Bañuelos-Pineda

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

R. Sarabia-Estrada

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

C. C. Gómez-Rodiles

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

E. Albarrán-Rodríguez

Div. Medicina Veterinaria Dpto. Neuromorfología C.U.C.B.A. UdeG, Mexico

G. P. Zaitseva

Div. Ciencias Biológicas y Ambientales Dpto. Biología Celular y Molecular C.U.C.B.A. UdeG, Mexico

M. L. Pita-López

Div. Ciencias Biológicas y Ambientales Dpto. Biología Celular y Molecular C.U.C.B.A. UdeG, Mexico

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.

Key Words: biomaterial • chitosan • sciatic nerve • immunological study • humoral immune response • cellular immune response

Journal of Biomaterials Applications, Vol. 18, No. 1, 15-23 (2003)
DOI: 10.1177/0885328203018001002
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[Abstract] [PDF]