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Biological Reactions to a Poly(l-lactide)—Hydroxyapatite Composite: A Study in Canine Mandible

Faculty of Dentistry, Department of Prosthodontics Hacettepe University Sihhiye, Ankara, Turkey

Saime Sahin

Faculty of Dentistry, Department of Prosthodontics Hacettepe University Sihhiye, Ankara, Turkey

Kemal Kesenci

Chemical Engineering Department and Bioengineering Division Hacettepe University TÜBITAK-Center of Excellence: POLBITEK Beytepe, Ankara, Turkey

Kadriye Tuzlakoglu

Chemical Engineering Department and Bioengineering Division Hacettepe University TÜBITAK-Center of Excellence: POLBITEK Beytepe, Ankara, Turkey

Erhan Piskin

Chemical Engineering Department and Bioengineering Division Hacettepe University TÜBITAK-Center of Excellence: POLBITEK Beytepe, Ankara, Turkey

Savas Özturk

Faculty of Veterinary Medicine, Department of Surgery University of Kafkas Kars, Turkey

Sevket Ruacan

Faculty of Medicine, Department of Pathology Hacettepe University Sihhiye, Ankara, Turkey

Biray Caner

Faculty of Medicine, Department of Nuclear Medicine Hacettepe University Sihhiye, Ankara, Turkey

Murat Fani Bozkurt

Faculty of Medicine, Department of Nuclear Medicine Hacettepe University Sihhiye, Ankara, Turkey

In this study, bone response, possible use and ultimate fate of a chemically-synthesized poly (L-lactide)-hydroxyapatite (PLLA-HA) composite was experimented in canine mandible. Bilateral mandibular second premolars were extracted in four dogs. The PLLA-HA composite was placed into left surgical sites, and right extraction sites were used as controls. After three months of healing, bone specimens were harvested from each animal and processed for histological evaluation. Bone uptake of methylene diphosphonate (99mTc-MDP) was calculated as indicators of osteoblastic activity in the surgical sites. Histological evaluation and the amount of 99mTc-MDP uptake showed that all surgical sites had similar levels of cellular activity and the material was biocompatible. The experimental PLLA-HA composite studied is safe to be used as a small-defect filler in applications such as repair of alveolar defects, ridge augmentations, and sinus lift procedures.

Key Words: poly(L-lactide) • hydroxyapatite • PLLA-HA composites • mandible • methylene diphosphonate • histology

Journal of Biomaterials Applications, Vol. 17, No. 4, 265-276 (2003)
DOI: 10.1177/0885328203017004002


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