Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Biomaterials Applications
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Actis, A. B.
Right arrow Articles by Bertolotto, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Actis, A. B.
Right arrow Articles by Bertolotto, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Enzymatic Treatments on the Biomechanical Properties of Screws Made of Bone

A. B. Actis

Cátedra ‘‘B’’ de Anatomía, Facultad de Odontología, Universidad, Nacional de Córdoba, Haya de la Torre s/n, Pabellón Argentina, ala izquierda, Ciudad Universitaria, 5000 Córdoba, Argentinaadractis{at}odo.unc.edu.ar

J. A. Obwegeser

Abteilung für Mund, Kiefer und Gesichtschirugie, Allgemeines öffentliches Krankenhaus der Stadt Linz, Krankenhausstr. 9, A-4020 Linz, Austria

P. Bertolotto

Sección Matemática, Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, 5000 Córdoba, Argentina

Nowadays, bone tissue employed to manufacture screws used as osteosynthesis material is obtained from organ donors. But in different medical fields there is an increasing need to use xenogenic grafts and implants, which still imply risks of transmission of some diseases and antigenicity.

Two different autoclaving programs (A1, A2) and an alternative to reduce the antigenicity of screws made of xenogenic bone based on enzymatic treatment are analyzed from a biomechanical point of view.

128 screws made of bovine femur bone were employed. Some of them were partially demineralized with 0.6 N HCl, enzymatically digested with collagenase (specific) and pepsin (nonspecific) and then autoclaved. The specimens were subjected to tension, shear and screw torque tests and histologically evaluated.

Compared to A1, A2 sterilization method (134°C but higher vacuum and longer time) considerably reduced the mechanical strength of specimens. The enzymatic digestion, expected to reduce antigenicity, did not affect the screw superficial structure and would not modify the bone biomechanical properties per se, but maybe because of the association with autoclaving and partial demineralization.

Key Words: screws • bone • demineralization • enzymatic digestion • xenogenic implants • antigenicity

Journal of Biomaterials Applications, Vol. 17, No. 3, 207-219 (2003)
DOI: 10.1177/0885328203017003548
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Biomater ApplHome page
D.P. Haje, J.B. Volpon, and C.A. Moro
Bovine Bone Screws: Metrology and Effects of Chemical Processing and Ethylene Oxide Sterilization on Bone Surface and Mechanical Properties
J Biomater Appl, March 1, 2009; 23(5): 453 - 471.
[Abstract] [PDF]