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Journal of Biomaterials Applications
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Stimuli Sensitive Polymethacrylic Acid Microparticles (PMAA) – Oral Insulin Delivery

Sunita Prem Victor

Biosurface Technology Division, BMT Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum 695 012, India

Chandra P. Sharma

Biosurface Technology Division, BMT Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum 695 012, Indiasharmacp{at}sctimst.ac.in

This study investigated polymethacrylic acid (PMAA) microparticles for controlled release of Insulin in oral administration. The microparticles were characterised by scanning electron microscopy (SEM) for morphological studies.The swelling behaviour and drug release profile in various pH media were studied. The% swelling of gels was found to be inversely related to the amount of crosslinker added. Inclusion complex of ßCD and Insulin was studied using polyacrylamide gel electrophoresis (PAGE). Optimum complexation was obtained in the ratio 100mg ßCD: 200IU Insulin. The release pattern of Insulin from Insulin–ßCD complex encapsulated PMAA microparticles showed release of Insulin for more than seven hours.

Key Words: hydrogel • PMAA • ß cyclodextrin • inclusion complex • optimisation • microparticles

Journal of Biomaterials Applications, Vol. 17, No. 2, 125-134 (2002)
DOI: 10.1106/088532802028583
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S. Sajeesh and C. P. Sharma
Poly Methacrylic Acid-Alginate Semi-IPN Microparticles for Oral Delivery of Insulin: A Preliminary Investigation
J Biomater Appl, July 1, 2004; 19(1): 35 - 45.
[Abstract] [PDF]