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Journal of Biomaterials Applications
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Regression of Solid Tumour Using Laser and 5-Aminolevulinic Acid in Mice

P. V. Mohanan

Toxicology Group, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695 011, Kerala, India

R. S. Jayasree

Department of Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695 011, Kerala, India

A. K. Gupta

Department of Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, 695 011, Kerala, Indiagupta{at}sctmist.ker.nic.in

Solid tumour reducing effect in Swiss albino mice induced with Dalton’s Lymphoma Ascites tumour cells (DLA) and Ehrlich Ascites tumour cells (EA) was determined with the application of He–Ne and Nd: YAG lasers along with the photosensitising agent 5-Aminolevulinicacid (ALA). The experiment was designed with six groups and each group consisted of six animals. Animals in Groups I–III were injected with DLA cell lines and Groups IV–VI were injected with EAcell lines (1 x 106 in 0.1 ml saline) subcutaneously in the right hind limb of mice to induce solid tumours. The tumour was further treated with photosensitiser induced laser therapy. The hyperthermic effect of Nd: YAG laser on tumour reduction was also evaluated. The results of the study suggest that the combination of He–Ne laser and 1 W Nd: YAG laser along with the photosensitiser 5-Aminolevulinic acid is a very effective therapeutic method for the treatment of tumour of DLA and EA cell lines. It is clear from the results that this mode of therapy very well depends on the type of tumour that has to be treated.

Key Words: Dalton’s Lymphoma Ascites cells • Ehrlich Ascites cells • solid tumour • He–Ne laser • Nd:YAG laser • photodynamic therapy

Journal of Biomaterials Applications, Vol. 16, No. 4, 267-274 (2002)
DOI: 10.1106/088532802022918
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