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In Vivo and in Vitro Stability of Modified Poly(Urethaneurea) Blood Sacs

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802

J. Runt

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, runt{at}ems.psu.edu

G. Felder

Department of Surgery, College of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033

G. Rosenberg

Department of Surgery, College of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033

A. J. Snyder

Department of Surgery, College of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033

W. J. Weiss

Department of Surgery, College of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033

J. Lewis

Arrow International, P.O. Box 6306, Reading, PA 19610

T. Werley

Arrow International, P.O. Box 6306, Reading, PA 19610

In the present study, we investigate the in vivo and in vitro stability of modified poly(urethaneurea) (BioSpan MS/0.4) blood sacs. Blood sacs were utilized primarily in left ventricular assist devices that were implanted in calves for times ranging from 5 to 160 days. Cyclic testing in vitro was also conducted on similar sacs. Various analytical methods were employed to characterize the sacs after in vivo or in vitro service and corresponding retained "control" sacs. These methods included ATR-FTIR spectroscopy, scanning electron microscopy and gel permeation chromatography. In general, the characteristics of implanted and in vitro cycled sacs were similar to their control sacs. Thermal and microtensile properties were unchanged after testing. The same was true for the ATR-FTIR spectra, indicating relative chemical stability for the time frames explored here. The only significant changes occurred in molecular weight and gross surface morphology. A modest increase in weight average molecular weight was observed for most implanted blood sacs, indicating some type of chain extension or branching reaction in vivo. Although the surface morphologies of implanted blood sacs were often similar to their control sacs, we sometimes observed limited pitting on the nonblood contacting surfaces in regions of the sac that experience maximum bending during service.

Key Words: polyurethaneurea • biodegradation • heart assist devices

Journal of Biomaterials Applications, Vol. 14, No. 4, 349-366 (2000)
DOI: 10.1177/088532820001400403


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