This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pandit, A. S. Articles by Thompson, J. A. Search for Related Content PubMed PubMed Citation Articles by Pandit, A. S. Articles by Thompson, J. A. Social Bookmarking                         What's this?

Fibrin Scaffold as an Effective Vehicle for the Delivery of Acidic Fibroblast Growth Factor (FGF-1)

Department of Biomedical Engineering, HOEN-370, 1075 So. 13th Street, University of Alabama at Birmingham, Birmingham, AL 35294

David J. Wilson, M.S.

Department of Biomedical Engineering, HOEN-370, 1075 So. 13th Street, University of Alabama at Birmingham, Birmingham, AL 35294

Dale S. Feldman, Ph.D.

Department of Biomedical Engineering, HOEN-370, 1075 So. 13th Street, University of Alabama at Birmingham, Birmingham, AL 35294

J. A. Thompson, Ph.D.

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294

The effect of wound healing by fibrin and acidic fibroblast growth factor (FGF-1) in an in vivo model was evaluated in this study. Four full-thickness wounds were made on the dorsum of each rabbit (n = 5). Each of these wounds had different treatment groups: control, topical FGF-1 (100 µg/9 cm²), fibrin (2.0 mL at 60 mg/mL fibrinogen), and FGF-1 (100 gg/9 cm²)/fibrin. The animals were sacrificed at the end of 2 weeks. Histomorphometric analysis and mechanical testing were conducted to assess the healing response. FGF-1/fibrin treatment improved the mechanical properties of the healed tissue. Fibrin scaffold exhibited the desired tissue response, as demonstrated by the lack of inflammation, and was deemed an effective carrier for FGF-1.

Key Words: wound healing • fibrin • acidic fibroblast growth factor

Journal of Biomaterials Applications, Vol. 14, No. 3, 229-242 (2000)
DOI: 10.1177/088532820001400303


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?