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Journal of Biomaterials Applications
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Effect of Stainless Steel Corrosion Products on in Vitro Biomineralization

Maria Helena Fernandes

Faculdade de Medicina Dentária da Universidade do Porto, Rua Dr Manuel Pereira da Silva, 4200 Porto, Portugal

Osteoblast-like cell cultures have been used as in vitro models to study the interactions of bone tissue with biomaterials and their degradation products. This work reviews the effects of AISI 316L stainless steel (SS) corrosion products on the osteoblastic behavior of rat and human bone cell cultures. Results suggest that such products affect, in a dose-]dependent manner, the proliferation and differentiation of osteoblastic cells; these effects depend on the developmental stage of the osteoblastic cells. Above certain nonlethal concentrations, SS corrosion products prevent the mineralization of the extracellular matrix, a process that reflects the complete expression of the osteoblastic phenotype.

Key Words: stainless steel corrosion products • osteoblastic cells • mineralization

Journal of Biomaterials Applications, Vol. 14, No. 2, 113-168 (1999)
DOI: 10.1177/088532829901400202
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