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Journal of Biomaterials Applications
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In Vitro Antimicrobial Activity of a New Antiseptic Central Venous Catheter

Chunhua Li

Abbott Laboratories, 755 Jarvis Drive, Morgan Hill, CA 95037

Xianping Zhang

STS Biopolymers, Inc., 336 Summit Point Drive, Henrietta, NY 14467

Richard Whitbourne

STS Biopolymers, Inc., 336 Summit Point Drive, Henrietta, NY 14467

A central venous catheter coated with a new antiseptic combination, silver chloride (AgCl) and benzalkonium chloride (BKC) in a polymer matrix, was developed. The antimicrobial efficacy and the ability to prevent surface colonization, after elution in both serum and saline, were evaluated and compared to catheters coated with silver sulfadiazine/chlorhexidine. The results of in vitro assays demonstrated that the AgCl-BKC coated catheters had a broad spectrum of activity against bacteria and C. albicans and prolonged antimicrobial activity for extraction periods of up to 30 days. These data suggest that AgCl-BKC coated catheters may provide another solution for reduction of catheter-related infections.

Key Words: Antimicrobial activity • surface coating • polyurethane catheter • catheter-related infection

Journal of Biomaterials Applications, Vol. 13, No. 3, 206-223 (1999)
DOI: 10.1177/088532829901300303
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