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Journal of Biomaterials Applications
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Polyethylene Glycol (PEG) Modified Bovine Pericardiuim as a Biomaterial: A Comparative Study on Immunogenicity

Sheeja Aravind K.

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum 695 012 India

Willi Paul

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum 695 012 India

Sindhu C. Vasudev

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum 695 012 India

Chandra P. Sharma

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum 695 012 India

Bioprosthetic heart valves made from glutaraldehyde (GA)-fixed porcine aortic valves or bovine pericardium (BP) are having some advantages over mechanical valves. However, their durability is low due to the calcification and immunological rejection. Study on immunogenicity is an important part in understanding the biocompatibility of materials. Polyethylene glycol (PEG) on pericardium can control biodegradation and calcification. Also, PEG exhibits low immunogenicity. We have studied the complement activation potential and the contribution of complement factors (biologic factors) on the calcification of PEG grafted pericardium samples and compared with standard (control) glutaraldehyde-treated pericardium samples. PEG-grafted BP activated using GA and carbodiimide (EDC) could be selected for further studies since complement activation and calcification observed on these samples has been relatively low.

Journal of Biomaterials Applications, Vol. 13, No. 2, 158-165 (1998)
DOI: 10.1177/088532829801300205
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S. C. Vasudev, T. Chandy, C. P. Sharma, M. Mohanty, and P. R. Umasankar
Effects of Double Cross-Linking Technique on the Enzymatic Degradation and Calcification of Bovine Pericardia
J Biomater Appl, January 1, 2000; 14(3): 273 - 295.
[Abstract] [PDF]