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Journal of Biomaterials Applications
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Hemorheological Parameters for Biocompatibility Evaluation

K. Nageswari

School of Biomedical Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai-400 076, India

R. Banerjee

School of Biomedical Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai-400 076, India

R. V. Gupte

School of Biomedical Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai-400 076, India

R. R. Puniyani

School of Biomedical Engineering, Indian Institute of Technology, Bombay, Powai, Mumbai-400 076, India

Biomaterials have been extensively used for various clinical applications. Since blood is very sensitive to the presence of any foreign substances, testing for hemocompatibility is a major part of biocompatibility evaluation. At present, blood viscosity parameters are being used as screening tests for biomaterial compatibility. Successful use of these parameters will help eliminate many in-compatible materials from being subjected to extensive testing. In this study, we evaluated the blood viscosity parameters (n = 10)-whole blood viscosity, plasma viscosity, red cell rigidity, hematocrit, and biochemical parameters (total proteins and albumin). A significant increase in hemorheological parameters after incubation with material was found to be an indicator of incompatibility.

Key Words: biomaterials • biocompatibility • hemorheology

Journal of Biomaterials Applications, Vol. 13, No. 1, 74-80 (1998)
DOI: 10.1177/088532829801300105
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