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Journal of Biomaterials Applications, Vol. 12, No. 3, 249-257 (1998)
DOI: 10.1177/088532829801200305

The Effects of Alginate and Non-Alginate Wound Dressings on Blood Coagulation and Platelet Activation

Helen C. Segal

Research Haematology Group, Harefield Hospital, Harefield, Middlesex, UK UB9 6JH

Beverley J. Hunt

Research Haematology Group, Harefield Hospital, Harefield, Middlesex, UK UB9 6JH

K. Gilding

Innovative Technologies Ltd., Road Three, Winsford Industrial Estate, Winsford, Cheshire, UK CW7 3PD

Alginates are used as haemostats in wound dressings. They act as calcium ion (Ca) donors as they contain mannuronic (M) or guluronic (G) groups with a high Ca content. This study compared the effects of calcium and zinc containing alginates and non-alginate dressings on blood coagulation and platelet activation to determine which was the best haemostat. We showed that alginate materials activated coagulation more than non-alginate materials. The extent of coagulation activation was affected differently by the alginate M or G group composition. It was demonstrated that alginates containing zinc ions had the greatest potentiating effect on prothrombotic coagulation and platelet activation.

Key Words: alginate • mannuronic • guluronic • calcium ions • zinc ions • coagulation • platelet activation • thrombin generation


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