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Journal of Biomaterials Applications
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Insolubilization Test of Sodium Chondroitin Sulphate with a View to its Use as Colonic Carrier of Drugs

C. Bourie

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

B. Paillard

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

E. Goutay

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

J. L. Avan

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

J. P. Combal

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

J. Bougaret

Pierre Fabre Research Institute, 45, Place Abel Gance, F-92654 Boulogne Cedex, France

J. M. Aiache

Biopharmaceutics Department, Faculty of Pharmacy, F-63001 Clermont-Ferrand Cedex, France

J. C. Jacquinet

Organic and Analytical Chemistry Institute, BP 6759, F-45067 Orléans Cedex 2, France

Several studies have been devoted to cross-linked sodium chondroitin sulphate (SCS), in the context of numerous strategies attempting to target the colon for the absorption or the therapeutic action of a drug. SCS, a glycosaminoglycan presenting a specific degradation in the colon, is in fact soluble in water and its use as drug carrier at such a distance from the digestive tube necessitates its hydrophobisation. One method described in the literature consists in manufacturing a three-dimensional network by cross-linking with bifunctional compounds. However, all the structural characterisations carried out on the products resulting from the catalysed treatments of SCS with diaminoalkanes demonstrate that there are no cross-linking bridges between the polymer chains. Moreover, treated SCS-based tablets containing theophylline as model drug lead in vitro to dissolution profiles which are identical to those obtained with the non-treated SCS. We were therefore unable to find the announced results using the method described.

Key Words: colonic targeting • biodegradation • sodium chondroitin sulphate (SCS) • cross-linking • insolubilisation

Journal of Biomaterials Applications, Vol. 12, No. 3, 201-221 (1998)
DOI: 10.1177/088532829801200302
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