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Journal of Biomaterials Applications
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Influence of Polyethylene Glycol Graftings on the in Vitro Degradation and Calcification of Bovine Pericardium

Sindhu C. Vasudev

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum-695 012, India

Thomas Chandy

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum-695 012, India

Chandra P. Sharma

Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum-695 012, India

Calcification is a frequent cause of the clinical failure of bio-prosthetic heart valves fabricated from glutaraldehyde pretreated bovine pericardium (GATBP). This article reports on various chemical techniques for grafting polyethylene glycol (PEG) on bovine pericardium, their biostability, and calcification. The process of calcification profile was studied by in vi- tro experiments via the incubation of pericardial samples in a metastable solution of calcium phosphate. The calcification profile of PEG-modified bovine pericardium through glutaraldehyde linkages was significantly reduced compared to other methods of grafting. The mechanical property of these PEG-modified tissues after enzyme (collagenase) digestion and calcification were also investigated. PEG grafting of BP via glutaraldehyde or hexamethylene diisocyanate had shown better mechanical stability compared to other grafting methods used.

In conclusion, it seems that the surface modification of bovine pericardium through high molecular weight PEGs via glutaraldehyde linkages may provide new ways of controlling tissue biodegradation and calcification.

Key Words: calcification • polyethylene glycol • bovine pericardium • colla-genase

Journal of Biomaterials Applications, Vol. 11, No. 4, 430-452 (1997)
DOI: 10.1177/088532829701100403
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S. C. Vasudev, T. Chandy, C. P. Sharma, M. Mohanty, and P. R. Umasankar
Effects of Double Cross-Linking Technique on the Enzymatic Degradation and Calcification of Bovine Pericardia
J Biomater Appl, January 1, 2000; 14(3): 273 - 295.
[Abstract] [PDF]