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In Vitro Release of New Quinolones from Biodegradable Systems: A Comparative Study

Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780 Zografou Athens, Greece

T. Korakis

Department of Orthopaedics, LAIKO General Hospital of Athens, 17 St. Thomas Str, 11527 Athens, Greece

E. Dounis

Department of Orthopaedics, LAIKO General Hospital of Athens, 17 St. Thomas Str, 11527 Athens, Greece

A. Anastasiadis

Department of Orthopaedics, LAIKO General Hospital of Athens, 17 St. Thomas Str, 11527 Athens, Greece

P. Tzivelekis

Department of Orthopaedics, LAIKO General Hospital of Athens, 17 St. Thomas Str, 11527 Athens, Greece

K. Kanellakopoulou

First Department of Propedeutic Medicine, Athens University School of Medicine, LAIKO General Hospital of Athens, 17 St. Thomas Str, 11527 Athens, Greece

A new biodegradable delivery system based on low molecular weight poly(lactic acid) has been formualted, with potential application in the sustained antibiotic release against bone infection. The in vitro release of two new quinolones (ofloxacin and ciprofloxacin) from the biodegradable matrix showed that the delivery of ofloxacin from the matrix lasted fifty-six days, whereas that of ciprofloxacin lasted fifty-one days. In both cases, release is controlled by the drug diffusion and the matrix degradation, the latter being the most critical factor. The obtained concentration levels are well above the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of osteomyelitis. This fact in combination with the good reproducibility of measurements indicated that the system studied could be of value for the preparation of implantable controlled release systems for treatment of diseases in the bone system.

Key Words: biodegradable polymers • drug delivery systems • new quino-lones • ofloxacin • ciprofloxacin

Journal of Biomaterials Applications, Vol. 10, No. 4, 338-347 (1996)
DOI: 10.1177/088532829601000404


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