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The Effect of Modification of Acrylic Resins on Controlled Release and Bioadhesion

Department of Pharmacy, Division of Pharmaceutical Technology, University of Athens, Panepistimiopolis 157 71, Zografou, Athens, Greece

N. H. Choulis

Department of Pharmacy, Division of Pharmaceutical Technology, University of Athens, Panepistimiopolis 157 71, Zografou, Athens, Greece

M. Efentakis

Department of Pharmacy, Division of Pharmaceutical Technology, University of Athens, Panepistimiopolis 157 71, Zografou, Athens, Greece

A. G. Andreopoulos

Department of Chemical Engineering, N.T.U. of Athens, 157 80 Zografou, Athens, Greece

The effect of various treatments on the properties of an acrylic matrix was studied, in terms of its swelling properties in buffer solution. The release of two types of drugs from those matrices and their bioadhesive character were also considered.

Calcium stearate and sodium lauryl sulfate were used as additives for the matrix treatment. 2-Hydroxyethyl methacrylate was also used as a reactive agent for the acrylic resin treatment. The main function of the above chemicals is the modification of the hydrophilic/hydrophobic character of the matrix.

This investigation showed that controlled release systems can be designed by adjusting the matrix properties via additives or chemical reaction.

Journal of Biomaterials Applications, Vol. 10, No. 3, 217-229 (1996)
DOI: 10.1177/088532829601000303


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