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Journal of Biomaterials Applications
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Development of Silastic Polyurethane (Angioflex) Materials with Antibacterial Agent

K. Rathinam

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, India

P. R. Hari

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, India

Chandra P. Sharma

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, India

J. Shanmugam

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, India

Bioimplants incorporated with antimicrobial agents are needed to control Foreign Body Associated Infection (FBAI) in clinical settings. Attempts are made here to develop five different types of polyurethane (Angioflex), viz., (1) bare polymer, (2) bare polymer glow discharged, (3) bare polymer coated with chlorhexidine, (4) chlorhexidine coated polymer glow discharged, and (5) material (4) recoated with another layer of chlorhexidine digluconate. These materials are tested for their in vitro antibacterial effects using disc diffusion technique against five different standard clinical staphylococcus strains, viz., Wood 46 (Staph. aureus), A 182 (Staph. epidermidis), A 313 (Staph. epidermidis), A 61 (Staph. epidermidis), and A 72 (Staph. epidermidis). Maximum antibacterial effects (zone of inhibition) are observed with polyurethanes incorporated with chlorhexidine digluconate (3) and chlorhexidine incorporated and glow discharged (4). Findings of this study indicate that glow discharge does not seem to produce either additive or synergistic antibacterial effects with chlorhexidine digluconate coated Angioflex material.

Journal of Biomaterials Applications, Vol. 10, No. 3, 210-216 (1996)
DOI: 10.1177/088532829601000302
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