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Journal of Biomaterials Applications
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Article

Effect of a New Titanium Coating Material (CaTiO3-aC) Prepared by Thermal Decomposition Method on Osteoblastic Cell Response

MIHO INOUE1*, ANDREA P. RODRIGUEZ1, TOHRU TAKAGI1, NAOKI KATASE1, MIDORI KUBOTA1, NORIYUKI NAGAI1, HITOSHI NAGATSUKA1, MASAHISA INOUE2, NORIYUKI NAGAOKA3, SHIN TAKAGI4, and KAZUOMI SUZUKI5

1 Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
2 Laboratory for Structure and Function, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-Cho Nishihamabouji, Tokushima, Japan
3 Laboratory for Electron Microscopy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
4 Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
5 Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

* To whom correspondence should be addressed. E-mail: mi8{at}md.okayama-u.ac.jp.


  Abstract

Titanium and hydroxyapatite (HA) are widely used as biomaterials for dental and medical applications. HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak because of the lack of chemical interaction between HA and titanium. A solution to this problem is to form an intermediate film on titanium substrate, which provide excellent adherence to both titanium substrate and HA. We developed a novel biomaterial called calcium titanate-amorphous carbon (CaTiO3-aC) coating prepared by modified thermal decomposition method. The purpose of this study was to evaluate the effect of CaTiO3-aC and HA coating (positive control), and Ti (negative control) on osteoblastic (MT3T3-E1) cell responses. An increased cellular proliferation was observed in CaTiO3-aC coating compared to HA coating. The maximum expressions of ALP activity, Col I and ALP mRNA were higher and achieved in shorter period of time in CaTiO3-aC coating compared to others. These results demonstrated that CaTiO3-aC promoted better cell attachment, cellular proliferation, and osteoblastic differentiation compared with HA. In conclusion, we suggested that CaTiO3-aC could be considered as an important candidate as a coating material.

First published on September 2, 2009
Journal of Biomaterials Applications 2009, doi:10.1177/0885328209340334
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