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Journal of Biomaterials Applications
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Article

Biological Response of Osteosarcoma Cells to Size-Controlled Nanostructured Hydroxyapatite

ZHONGLI SHI1, XIN HUANG1, BING LIU1, HUIMIN TAO1*, YURONG CAI2, and RUIKANG TANG2

1 Department of Orthopaedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China
2 Department of Chemistry and Centre of Biomaterials and Biopathways, Zhejiang University, Hangzhou 310027, China

* To whom correspondence should be addressed. E-mail: hmtao-zr{at}163.com.


  Abstract

Osteosarcoma is a primary malignant bone tumor, most prevalent in children and adolescents, and is usually highly aggressive and eventually lethal. Despite multimodal therapies, there is no effective approach to treat this malignant disease. In this study, we observed the biological response of osteosarcoma cells to two kinds of hydroxyapatite nanoparticles (Nano HA), NanoHA-S and NanoHA-L. These nanospheres have the same crystallinity (phase) and morphology, but they differ in size. Cells treated with two kinds of Nano HA were inhibited and mainly led to apoptotic cell death. Caspase-9-dependent intrinsic apoptotic pathway plays a role. It was interesting that the suppression and the apoptosis of osteosarcoma cells was directly related to the size of nanoparticles and that the larger-sized Nano HA exhibited more effectiveness than the smaller one. This in vitro study suggested the potential of size-controlled calcium phosphate nanoparticles for use in therapeutic replacement and reconstruction of bone merits after osteosarcoma extraction.

First published on September 2, 2009
Journal of Biomaterials Applications 2009, doi:10.1177/0885328209339396
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