This Article Full Text (OnlineFirst PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ahmed, I. Articles by Rudd, C. Search for Related Content PubMed PubMed Citation Articles by Ahmed, I. Articles by Rudd, C. Social Bookmarking                         What's this?

Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-Based Glasses

University Park Campus

^* To whom correspondence should be addressed. E-mail: Ifty.Ahmed{at}nottingham.ac.uk.

	Abstract

Recently, phosphate-based glass (PBG) fibers have been used to reinforce the biodegradable polymers polycaprolactone and polylactic acid, in order to fabricate materials suitable for use as resorbable bone fracture fixation devices. However, the PBG fibers investigated tended to degrade too quickly for application. Therefore, more durable PBG formulations were sought with emphasis remaining firmly placed on their biocompatibility. In this study, four invert PBG formulations (in the system P₂O₅–CaO–MgO–Na₂O) were produced with fixed phosphate and calcium content at 40 and 25 mol%, respectively. MgO was added at 10–30 mol% in place of Na₂O and the maximum divalent cation to phosphate ratio obtained was 1.375. Thermal analyses showed a linear increase in T_g with increasing MgO content. This was proposed to be due to an increase in the cross-link density of the glass network, which also improved the chemical durability of the glass. EDX analyses were also conducted to verify the final composition of the glass. XRD analyses confirmed the amorphous nature of the glasses investigated. Rapid quenching of the Mg30 glass revealed a degree of surface crystallization, which was shown to be a CaMgP₂O₇ phase. The degradation rates of the glasses investigated decreased with increasing MgO content. The decrease in rate seen was almost two orders of magnitude (a x50 difference was seen between glass Mg0 and Mg30). The cytocompatibility studies of the formulations investigated showed good cellular response over time for up to 14 days. Statistical analysis revealed that the formulations investigated gave a response comparable to the tissue culture plastic control. It is suggested that invert PBG provide degradation profiles and the cytocompatibility response desired to make these glasses useful for bone repair applications.

First published on April 22, 2009
Journal of Biomaterials Applications 2009, doi:10.1177/0885328209102761


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?