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Journal of Biomaterials Applications
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Article

Novel Polymeric Coatings with the Potential to Control In-stent Restenosis – An In Vitro Study

C.M. Nickson*, P.J. Doherty, and R.L. Williams

Clinical Engineering, School of Clinical Sciences, University of Liverpool Duncan Building, Daulby Street, Liverpool, L69 3GA

* To whom correspondence should be addressed.


  Abstract

Restenosis following percutaneous coronary intervention (PCI) is a considerable problem in long-term performance of cardiovascular stents, with a functional endothelial cell monolayer being important in its prevention. This study evaluates the influence of polymer coatings on human aortic endothelial cells (HAEC) and coronary artery smooth muscle cells (HCASMC) in vitro, in terms of morphology, cell number, and phenotype. It was demonstrated that the polymer coatings can be tailored to enhance adhesion and growth of HAECs whilst suppressing that of HCASMCs. It is concluded that one of the polymer coatings (BTL 01015) shows potential as a stent coating to enhance re-endothelialization.

Key Words: coating, stent, restenosis, coronary, endothelial cell, smooth muscle cell, polymer.

First published on November 25, 2008
Journal of Biomaterials Applications 2008, doi:10.1177/0885328208099338
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